Chemistry 326: Introduction

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In this course, you will be finding information to support your Capstone creative project including the in-class presentation.  Use this guide as a starting point for key resources, search strategies, evaluating sources, and how to cite your sources.  Please email me to schedule research appointments as needed.

1.  Professor Blair has provided some suggested topics.  Do a quick literature search and, as a group, select one for your in-class seminar and final paper.

• Covalent inhibitors of protein kinases
• Drugging the undruggable: inhibition of K-RAS G12C
• Activity-based protein profiling
• Photoaffinity labeling in chemical biology
• Targeted protein degradation in live cells: PROTACs
• DNA-programmed combinatorial chemistry for novel drugs
• Bioorthogonal ligation reaction for imaging live cells\
• Recent advances in antibody-drug conjugates
• Mass spectrometry and target validation in drug discovery

2.  Revisit a topic from an earlier class.  Be sure to focus on the biophysical chemistry of the topic!

3.  Explore the textbook for ideas.